Experiment No. 8 Neutralizing capacity of aluminum hydroxide gel

 

Aim: To estimate the neutralizing capacity of aluminium hydroxide gel I.P 2010

Synonym: Aluminium hydroxide suspension, Aluminium hydroxide mixture

Reference: 1) Indian Pharmacopoeia 2010 vol II, page no 788.

                   2) The International Pharmacopoeia - Sixth Edition, 2016

Requirements:

Chemicals & Reagents: Dried aluminium hydroxide, 0.1 M hydrochloric acid, 0.1 M sodium hydroxide

Glassware: Burette, beaker, funnel, glass rod, conical flask, measuring cylinder.

Description: A white, viscous suspension translucent in thin layers; small amounts of clear liquid may separate on standing. Aluminium Hydroxide Gel is an aqueous suspension of hydrated aluminium oxide together with varying quantities of basic aluminium carbonate and bicarbonate. It may contain Glycerin, Sorbitol, Sucrose or Saccharin as sweetening agents and peppermint oil or other suitable flavours. It may also contain suitable antimicrobial agents.Aluminium Hydroxide Gel contains not less than 3.5 per cent and not more than 4.4 percent w/w of Al2O3

Category: Antacid

Procedure: Disperse 5.0 g in 100 ml of water, heat to 37  ̊C, add 100.0 ml of 0.1 M hydrochloric acid previously heated to 37  ̊C and stir continuously, maintaining the temperature at 37   ̊C; the pH of the solution, at 37  ̊C, after 10, 15 and 20 minutes, is not less than 1.8, 2.3 and 3.0 respectively and at no time is more than 4.5. Add 10.0 ml of 0.1 M hydrochloric acid previously heated to 37   ̊C, stir continuously for 1 hour maintaining the temperature at 37  ̊C and titrate with 0.1 M sodium hydroxide to pH 3.5.

Observation

 

Calculation

 

 

Result

The neutralizing capacity of aluminium hydroxide gel was found to be ………………


Youtube Video - Determination of acid neutralising Capacity of antacid formuation


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