BP110P PHARMACEUTICAL INORGANIC CHEMISTRY (Practical)

AIM: Preparation of Ferrous Sulphate  REFERENCES 1. Inorganic medicinal and pharmaceutical chemistry. Block, Roche, Soine, Wilson.  2. Indian Pharmacopoeia, 1996, 2016.  3. Available at: www.crscientific.com/ferroussulfate.html. Theory: Iron is a transitional element in periodic table. Iron compounds are used in medicine as an important constituent and the ores are widely distributed which includes haematite Fe2O3, limonite 2Fe2O3.3H O, magnetic iron are Fe3O4. The earth’s core consists largely of iron. Iron shows two oxidation states – Ferrous and Ferric. Ferrous sulphate is otherwise known as “green vitriol” and used as a reducing agent in chemistry. For the preparation with sulphuric acid the very first step is to determine the amount of impurity as sulphuric acid tolerable by the crystals which may result in chemical burns on touching if the amount of sulphuric acid content will be higher. The lab temperature has to be kept low or below 25°C. In the experiment we can take direct ir

 AIM: To prepare and submit Boric acid.   REFERENCE 1.         Singh H.R., Kapoor V.K. “Practical Pharmaceutical chemistry”, Vallabh Prakashan,  Ed I st , 2008, pp 23-24. 2.         Chatwal G.R, “Pharmaceutical chemistry inorganic” Himalaya publishing house, Ed 5 th , 2010, pp 127-128.   REQUIREMENTS Chemical required: Borax (Na 2 B 4 O 7 ) , Dilute sulphuric acid (H 2 SO 4 )   Apparatus required: Beaker, Pipette, Measuring cylinder, glass rod, funnel.   THEORY Synonyms: Boro flax, Boracic acid Chemical formula : H3BO3 Molecular weight : 61.83 Boric acid is a weak acid. It is a local anti-infective agent possessing weak bacterostatic and fungistatic properties. Anti-infective agent are the compound which reduce or prevent infection from the microbes like bacteria, fungi and protozoa. Na 2 B 4 O 7 + H 2 SO 4 + 5H 2 O → 4 H 3 BO 3 + Na 2 SO 4   PROCEDURE ·          Take 5 g of borax in a beaker and diss

Aim:  Determination of iodine (as KI) – Titration method  Reagents  1. Methyl orange indicator – Dissolve 0.50 g of methyl orange in water and dilute to one litre.  2. Dilute sulphuric acid – approximately 2 N.  3. Bromine water – Saturated aqueous solution. Determine the approximate concentration (mg/ml) by adding (from a burette) a measured volume to a flask containing 5 ml of 10 per cent potassium iodide solution, adding 5 ml of dilute sulphuric acid and titrating the liberated iodine with 0.1 N sodium thiosulphate solution.  4. Sodium sulphite solution – approximately one per cent (m/v).  5. Phenol solution – approximately 5 per cent (m/v).  6. Potassium iodide solution – approximately 10 per cent (m/v).  7. Standard sodium thiosulphate solution – 0.005 N (freshly standardized).  8. Starch solution – 1 per cent (freshly prepared) (m/v).  9. Sodium chloride solution – Dissolve 10 g of sodium chloride in water and make up the volume to 100 ml.  10. Potassium iodide control solution –

  Aim: To estimate the neutralizing capacity of aluminium hydroxide gel I.P 2010 Synonym:  Aluminium hydroxide suspension, Aluminium hydroxide mixture Reference: 1)  Indian Pharmacopoeia 2010 vol II, page no 788.                    2) The International Pharmacopoeia - Sixth Edition, 2016 Requirements: Chemicals & Reagents: Dried aluminium hydroxide, 0.1 M hydrochloric acid, 0.1 M sodium hydroxide Glassware: Burette, beaker, funnel, glass rod, conical flask, measuring cylinder. Description:  A white, viscous suspension translucent in thin layers; small amounts of clear liquid may separate on standing. Aluminium Hydroxide Gel is an aqueous suspension of hydrated aluminium oxide together with varying quantities of basic aluminium carbonate and bicarbonate. It may contain Glycerin, Sorbitol, Sucrose or Saccharin as sweetening agents and peppermint oil or other suitable flavours. It may also contain suitable antimicrobial agents.Aluminium Hydroxide Gel contains not less than 3

  Aim: To determine the swelling power of Bentonite Reference:  Indian Pharmacopoeia 2010 vol II, page no 877. Requirements: Chemicals & Reagents: Bentonite, 1% sodium lauryl sulphate solution Glassware: Measuring cylinder, beaker Description:  Bentonite is a natural, colloidal, hydrated aluminium silicate that has been processed to remove grit and non-swelling components of the ore. A very fine, pale buff or cream-coloured to greyish-white powder, free or almost free from gritty particles. Category:  Pharmaceutical aid (suspending agent) Procedure:  Add 2.0 g of bentonite in 20 portions at intervals of 2 minutes to 100 ml of a 1 per cent w/v solution of sodium lauryl sulphate in a 100 ml graduated cylinder about 3 cm in diameter. Allow each portion to settle before adding the next and let it stand for 2 hours. Observation table: Sr. No Time Volume of sediment (ml) 1 After 1 hour   2

Magnesium hydroxide  Ferrous sulphate  Sodium   Bicarbonate  Copper sulphate Aim: To perform the identification test for ferrous sulphate Reference:  Dr. N. Sharma,   Practical Inorganic Pharmaceutical Chemistry And Viva Voce, Birla Publications Pvt. Ltd., I st  edition, Page no. 83-84. Requirements: Chemicals & Reagents: Ferrous sulphate crystals, dilute H 2 SO 4 , phenanthroline, ceric ammonium sulphate, potassiun ferricyanide, dilute HCl, potassiun ferrocyanide, barium chloride, lead acetate, ammonium acetate, dilute NaOH, iodine solution, strontium chloride. Glassware: Test tube, beaker, funnel watch glass, spatula Chemical Formula:  FeSO 4 .7H 2 O Theory:  Ferrous sulfate occurs as a crystalline bluish green powder. It has a tendency to rapidly oxidize on exposure to moist air. It is odorless and is characterized through its metallic taste (styptic) taste. It is soluble in water but insoluble in alcohol. Use:  It is used as an important hematinic agent in various iron formulat